DEVELOPMENT AND CHARACTERIZATION OF SELF-HEALING TRANSDERMAL PATCH OF LIDOCAINE FOR THE MANAGEMENT OF PAIN

Pain management is a significant challenge due to the side effects associated with commonly prescribed medications like NSAIDs and opioids. Local anesthetics, such as lidocaine, offer an alternative fewer when formulated in topical patches. Transdermal delivery systems, including heated patches, enhance drug absorption provide targeted pain relief. This research paper aims develop characterize self-heating transdermal patch of lidocaine for management. The sample was characterized using UV-visible spectrophotometric analysis, melting point determination, differential scanning calorimetry. results confirmed purity sample. Pre-formulation studies were conducted determine solubility partition coefficient well drug-excipient interaction studies. formulation included selection excipients solvents, adhesives, solubilizers, permeation enhancers. developed three trial batches, final batch prepared drug-in-adhesive type approach. evaluated physical characteristics, solvent residual content, rolling ball test, shear strength, crystallization, in-vitro permeation. evaluation showed that had desired uniform thickness, good folding endurance, appropriate content. It exhibited satisfactory test strength. Microscopic examination absence crystallization. content determined be within range, study demonstrated successful release through dialysis membrane. In conclusion, development characterization promising approach effective suitable properties, suggesting its potential solution. KEYWORDS: Lidocaine, patch, management, self-heating,